|
KMID : 0616120100410010031
|
|
Korean Journal of Pharmacognosy
2010 Volume.41 No. 1 p.31 ~ p.37
|
|
|
A Study on the Anti-inflammatory and Anti-allergic Effect of Salvia plebeia R. extracts
|
|
Jo Sun-Young
Lee Ui-Young
Kim Eun-Young
Lee Sue-Jung
Her Jin-Woo
Yoon Taek-Joon
|
|
|
Abstract
|
|
|
The Salvia plebeia R. which is the biennial plant belonging to the Labiatae department, grows naturally in the Korea entire area. Presently, its extract (SPRE) is known to have an anti-inflammation and anti-allergy activity, but there are a few
evidences about it. SPRE inhibits pro-inflammatory cytokine such as TNF-α and IL-6 as well as nitric oxide (NO) production in lipopolysaccharide (LPS) treated- macrophages. The co-administration of SPRE during OVA sensitization significantly reduced total IgE levels in mice. The mice who received SPRE co-administered with OVA showed a significant increase in serum OVA-specific IgG2a/b levels. Spleen-cell cultures harvested from OVA-sensitized mice showed a significant decrease in Th2 cytokine levels with a concomitant increase in Th1 cytokine levels only when SPRE co-administered with OVA. These results demonstrate that SPRE can control the LPS-induced inflammatory reaction and prevent antigen-induced Th2 immune responses in mice.
|
|
|
KEYWORD
|
|
|
S. plebeia, inflammatoty cytokine, nitric oxide, obalbumin, IgE
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|